Using gene chips to count DNA copy numbers
نویسندگان
چکیده
منابع مشابه
Copy numbers count for autism
Mind image: Autism is characterized by a triad of impairments to social behaviour, communication and imagination. One school of thought claims that individuals with autism lack a ‘theory of mind’, implying that they don’t have a concept of themselves and other people as distinct, thinking personalities with their own beliefs, desires, etc. (Photo: N.H. Gross.) Autism, a neurodevelopmental disor...
متن کاملJoint Analysis of DNA Copy Numbers and Gene Expression Levels
Genomic instabilities, amplifications, deletions and translocations are often observed in tumor cells. In the process of cancer pathogenesis cells acquire multiple genomic alterations, some of which drive the process by triggering overexpression of oncogenes and by silencing tumor suppressors and DNA repair genes. We present data analysis methods designed to study the overall transcriptional ef...
متن کاملShould the numbers count?
Your use of the JSTOR archive indicates your acceptance of JSTOR's Terms and Conditions of Use, available at http://www.jstor.org/about/terms.html. JSTOR's Terms and Conditions of Use provides, in part, that unless you have obtained prior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content in the JSTOR archive only for your perso...
متن کاملAssociation test of multiallelic gene copy numbers in family trios.
While recent genomic surveys reveal growing numbers of di-allelic copy number variations, it is genes with multiallelic (>2) copy numbers that have shown association with distinct phenotypes. Current high-throughput laboratory methods are restricted to enumerating total gene copy numbers (GCNs) per individual and not the "genotype," i.e. gene copy per chromosome. Thus, association studies of mu...
متن کاملDNA Chips: from elaboration to application
The Nucleic Acids (DNA and RNA) are molecules holding the genetic information in all life cells and constitute the crucial and fundamental component of genes monitoring the working of living organisms. The scientific projects actually put in place through the world indicate clearly the strategic importance of the complete gene knowledge of wide varieties of live materials (Human Genomic Sequenc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Biology
سال: 2000
ISSN: 1474-760X
DOI: 10.1186/gb-2000-1-1-reports011